Degranulation MastPhosphatases Involved in IgE - Mediated Small Interfering RNA Screen for Alina Barbu and Reuben
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Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation.
Mast cells play pivotal roles in the initiation of the allergic response. To gain an understanding of the functions played by phosphatases in IgE-mediated mast cell activation, a small interfering RNA (siRNA) library that targets all mouse phosphatase genes was screened in a mouse mast cell line, MMC-1. Of 198 targets, 10 enhanced and 7 inhibited FcepsilonRI-induced degranulation. For seven of ...
متن کاملDegranulation MastPhosphatases Involved in IgE - Mediated Small Interfering RNA Screen for
Mast cells play pivotal roles in the initiation of the allergic response. To gain an understanding of the functions played by phos-phatases in IgE-mediated mast cell activation, a small interfering RNA (siRNA) library that targets all mouse phosphatase genes was screened in a mouse mast cell line, MMC-1. Of 198 targets, 10 enhanced and 7 inhibited Fc«RI-induced degranulation. For seven of the s...
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